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A 83-01
CAS No. 909910-43-6
A 83-01 ( A83-01 | A-83-01 )
产品货号. M16535 CAS No. 909910-43-6
一种有效的选择性 TGF-β I 型受体 ALK-5、ALK-4 和 ALK-7 抑制剂，IC50 分别为 12、45 和 7.5 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥429 | 有现货 |
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| 10MG | ￥721 | 有现货 |
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| 50MG | ￥2179 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称A 83-01
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种有效的选择性 TGF-β I 型受体 ALK-5、ALK-4 和 ALK-7 抑制剂，IC50 分别为 12、45 和 7.5 nM。
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产品描述A potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively; dispalys weak or no inhibitory activity again transcriptional activity of ALK6 and ALK1/2/3; prevents phosphorylation of Smad2/3 and the growth inhibition induced by TGF-beta with no effects on BMP signaling, ERK and p38 MAPK.
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体外实验A 83-01 (GMP) induces human foreskin fibroblasts converts into ardiomyocyte-like cells a more open-chromatin conformation at key heart developmental genes.A 83-01 (GMP) induces cord blood or fetal liver-derived CD34+ cells converts into pluripotent cells.
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体内实验A 83-01 (GMP) (human foreskin fibroblast with aMHC-GFP; incubates in vitro 6 days than transplanted into the infarcted hearts of immunodeficient mice) induces fibroblasts converts into cardiomyocyte-like cells in infarcted mouse heart.
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同义词A83-01 | A-83-01
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通路TGF-beta/Smad
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靶点TGFBR
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受体ALK4|ALK5|ALK7
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研究领域Cancer
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适应症——
化学信息
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CAS Number909910-43-6
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分子量421.5168
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分子式C25H19N5S
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESS=C(N1N=C(C2=NC(C)=CC=C2)C(C3=CC=NC4=CC=CC=C34)=C1)NC5=CC=CC=C5
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化学全称1H-Pyrazole-1-carbothioamide, 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Tojo M, et al. Cancer Sci. 2005 Nov;96(11):791-800.
2. Yuan X, et al. Stem Cells. 2011 Mar;29(3):549-53.
3. Yamamura S, et al. Int J Cancer. 2012 Jan 1;130(1):20-8.
4. Minowa T, et al. Br J Cancer. 2009 Dec 1;101(11):1884-90.
